Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Mus musculus | - |
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8R071 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | ITPKA is mainly expressed in pyramidal cells of the hippocampal CA1 region and granule cells of the dentate gyrus | Mus musculus | - |
Caco-2 cell | - |
Mus musculus | - |
carcinoma cell | - |
Mus musculus | - |
central nervous system | - |
Mus musculus | - |
dentate gyrus | - |
Mus musculus | - |
granule cell | - |
Mus musculus | - |
hippocampus | - |
Mus musculus | - |
lung cancer cell | - |
Mus musculus | - |
additional information | isozyme ITPKA is mainly expressed in neurons of the central nervous system and is also overexpressed in tumor cells | Mus musculus | - |
neuron | in mature neurons, ITPKA accumulates at postsynaptic densities (PSDs), where the protein is bound to F-actin | Mus musculus | - |
pyramidal neuron | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Mus musculus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
inositol-1,4,5-trisphosphate 3-kinase | - |
Mus musculus |
InsP3Kinase | - |
Mus musculus |
ITPKA | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | Itpka-deficient mice exhibit a weak metabolic phenotype, in keeping with functional studies revealing no clear role of ITPKA in metabolic organs. Broad phenotypic screening of itpka-deficient mice, Effects of itpka deficiency on brain function, overview. Among the neurobehavioral tests analyzed, itpka-deficient mice reacted faster to a hot plate, prepulse inhibition is impaired and the accelerating rotarod test shows decreased latency of itpka deficient mice to fall. Analysis of extracerebral functions in control and itpka deficient mice reveals significantly reduced glucose, lactate, and triglyceride plasma concentrations in itpka-deficient mice. Itpka deficiency affects energy metabolism, phenotype. Reduced glucose level is measured in plasma of itpka-deficient mice | Mus musculus |
physiological function | isozyme ITPKA is involved in the regulation of nociceptive pathways, sensorimotor gating, and motor learning. Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is the neuronal isoform of ITPKs and exhibits both actin bundling and InsP3 kinase activity. In addition to neurons, ITPKA is ectopically expressed in tumor cells, where its oncogenic activity increases tumor cell malignancy. ITPKA is involved in the regulation of nociceptive pathways, sensorimotor gating and motor learning. ITPKA plays a functional role in calcium signaling of CaCo-2 cells | Mus musculus |